Magnetically-induced heat from magnetic nanoparticle hyperthermia is considered as an effective method to treat cancer cells. In this work, to study the thermal properties of magnetic nanoparticles after induction heating, we first investigate the magnetic fluid hyperthermia experimentally. Different types of nanoparticles combined with various liquid for better thermal characteristics, like Iron oxide, magnetite, maghemite or even gold are injected in tumor then subjected to a high-frequency magnetic field. It is reported that these nanoparticles will produce substantial heat that typically increases the tumor temperature, which can treat cancer cells, and another major potential of magnetic nanoparticles is the ability to combine heat (hyperthermia) and drug release for a cancer treatment. Soy protein isolate (SPI) was hydrolyzed by compound enzymes to give water soluble low molecular soy protein (SP). SP and folic acid (FA) modified SP was polymerized with N-3-acrylamidophenylboronic acid (APBA) monomer in aqueous solution to give SP nanoparticles (SP NPs) and FA-modified nanoparticles (FA-SP NPs), respectively and all these results demonstrated that conjugation of FA can efficiently enhance SP-based NPs' tumor accumulation and antitumor effect. Then based on the results of an experiment, FEM numerical simulation was further employed.